Anatomy

Biotechnology

Organic chemistry

In vivo

Polycaprolactone

Biology

Nerve guidance conduit

Biomedical engineering

Surgery

Regeneration (biology)

Chemistry

Peripheral nerve injury

Reinnervation

Axon

Tissue engineering

Scaffold

Cell biology

Transplantation

Peripheral nerve

Polymer

Medicine

Advanced Science

Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting. Nevertheless, limited availability of autografts and potential morbidities in donors hampers its widespread application. Bioactive scaffold-based tissue engineering is a promising strategy to promote nerve regeneration. Additionally, magnesium (Mg) ions enhance nerve regeneration; however, an effectively controlled delivery vehicle is necessary to optimize their in vivo therapeutic effects. Herein, a bisphosphonate-based injectable hydrogel exhibiting sustained Mg

Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration