Last. Yuanjin Zhao(SEU: Southeast University)H-Index: 55
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Electronic skins have received increasing attention in biomedical areas. Current efforts about electronic skins are focused on the development of multifunctional materials to improve their performance. Here, the authors propose a novel natural-synthetic polymers composite structural color hydrogel film with high stretchability, flexibility, conductivity, and superior self-reporting ability to construct ideal multiple-signal bionic electronic skins. The composite hydrogel film is prepared by usin...
Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which are due to lack of comprehensive neuroprotective effects. Herein, a macrophage-disguised honeycomb manganese dioxide (MnO2 ) nanosphere loaded with fingolimod (FTY) is developed to salvage the ischemic penumbra. In particular, the biomimetic nanoparticles can accumulate actively in the damaged brain via macrop...
#2Changye Zou(SYSU: Sun Yat-sen University)H-Index: 3
Last. Qi Cao(NU: Northwestern University)H-Index: 33
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Liquid-liquid phase-separated (LLPS) transcriptional factor assemblies at super-enhancers (SEs) provide a conceptual framework for underlying transcriptional control in mammal cells. However, the mechanistic understanding of LLPS in aberrant transcription driven by dysregulation of SEs in human malignancies is still elusive. By integrating SE profiling and core regulatory circuitry (CRC) calling algorithm, the CRC of metastatic and chemo-resistant osteosarcoma is delineated. CRC components, HOXB...
Nanoformulations show great potential for delivering drugs to treat brain tumors. However, how the mechanical properties of nanoformulations affect their ultimate brain destination is still unknown. Here, a library of membrane-crosslinked polymersomes with different elasticity are synthesized to investigate their ability to effectively target brain tumors. Crosslinked polymersomes with identical particle size, zeta potential and shape are assessed, but their elasticity is varied depending on the...
Respiratory tract microbiome is closely related to respiratory tract infections, while characterization of oropharyngeal microbiome in recovered coronavirus disease 2019 (COVID-19) patients is not studied. Herein, oropharyngeal swabs are collected from confirmed cases (CCs) with COVID-19 (73 subjects), suspected cases (SCs) (36), confirmed cases who recovered (21), suspected cases who recovered (36), and healthy controls (Hs) (140) and then completed MiSeq sequencing. Oropharyngeal microbial α-d...
Last. Ya Yang(CAS: Chinese Academy of Sciences)H-Index: 30
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Multifunctional chemical sensing is highly desirable in industry, agriculture, and environmental sciences, but remains challenging due to the diversity of chemical substances and reactions. Surface-enhanced infrared absorption (SEIRA) spectroscopy can potentially address the above problems by ultra-sensitive detection of molecular fingerprint vibrations. Here, a multifunctional chemical sensing platform based on dual-resonant SEIRA device for sensitive and multifunctional on-chip detection of po...
#2Tianyiyi He(NUS: National University of Singapore)H-Index: 21
Last. Chengkuo Lee(NUS: National University of Singapore)H-Index: 66
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Lower-limb motion monitoring is highly desired in various application scenarios ranging from rehabilitation to sports training. However, there still lacks a cost-effective, energy-saving, and computational complexity-reducing solution for this specific demand. Here, a motion capturing and energy harvesting hybridized lower-limb (MC-EH-HL) system with 3D printing is demonstrated. It enables low-frequency biomechanical energy harvesting with a sliding block-rail piezoelectric generator (S-PEG) and...
The encapsulation and/or surface modification can stabilize and protect the phosphorescence bio-probes but impede their intravenous delivery across biological barriers. Here, a new class of biocompatible rhenium (ReI ) diimine carbonyl complexes is developed, which can efficaciously permeate normal vessel walls and then functionalize the extravascular collagen matrixes as in situ oxygen sensor. Without protective agents, ReI -diimine complex already exhibits excellent emission yield (34%, λem nu...
Last. Yi Liu(LBNL: Lawrence Berkeley National Laboratory)H-Index: 60
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Two frontier crystalline porous framework materials, namely, metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), have been widely explored owing to their outstanding physicochemical properties. While each type of framework has its own intrinsic advantages and shortcomings for specific applications, combining the complementary properties of the two materials allows the engineering of new classes of hybrid porous crystalline materials with properties superior to the individual ...