Internal medicine

Nuclear medicine

Radionuclide therapy

Cancer

Fibroblast activation protein, alpha

Medical physics

Radionuclide imaging

Medicine

European Journal of Nuclear Medicine and Molecular Imaging

Fibroblast activation protein (FAP) is a membrane-bound protease that has limited expression in normal adult tissues but is highly expressed in the tumor microenvironment of many solid cancers. FAP-2286 is a FAP-binding peptide coupled to a radionuclide chelator that is currently being investigated in patients as an imaging and therapeutic agent. The potency, selectivity, and efficacy of FAP-2286 were evaluated in preclinical studies.

Preclinical evaluation of FAP-2286 for fibroblast activation protein targeted radionuclide imaging and therapy