Phenotype

Genetic screen

Adenomatous polyposis coli

Familial adenomatous polyposis

Bacteria

Colorectal cancer

Carcinogenesis

Biology

Gene

Cancer

Genome

Whole genome sequencing

Bacteroides

Bacteroides fragilis

Mutation

Cancer research

Genetics

DNA mismatch repair

Microbiology Spectrum

Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, whether specific mutations induced by ETBF lead to colon tumor formation has not been investigated. To determine if ETBF-induced mutations impact the

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene