Sodium

Engineering

Diethyl carbonate

Yield (engineering)

Dimethyl carbonate

Sodium carbonate

Grignard reaction

Mechanochemistry

Metallurgy

Materials science

Alkyl

Methanol

Solvent

Ethylene carbonate

Inorganic chemistry

Chemical engineering

Carbonate

Synthon

Ball mill

Physical chemistry

Medicinal chemistry

Organic chemistry

Potassium carbonate

Reagent

Grignard reagent

Chemistry

Aryl

Electrode

Carbon dioxide

Electrolyte

Angewandte Chemie International Edition

A one‐pot, three‐step protocol for the preparation of Grignard reagents from organobromides in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO 2 ) or sodium methyl carbonate providing aryl and alkyl carboxylic acids in up to 82 % yield is reported. Noteworthy are the short reaction times and the significantly reduced solvent amounts [2.0 equiv. for liquid assisted grinding (LAG) conditions]. Unexpectedly, aryl bromides with methoxy substituents lead to symmetric ketones as major products.

Mechanochemical Grignard Reactions with Gaseous CO<sub>2</sub> and Sodium Methyl Carbonate**

Mechanochemical Grignard Reactions with Gaseous CO2 and Sodium Methyl Carbonate**

Mechanochemical Grignard Reactions with Gaseous CO₂ and Sodium Methyl Carbonate**