Intensive care medicine

Weight-bearing

Surgery

Bone remodeling

Insufficiency fracture

Physical therapy

Internal medicine

Medicine

Stress fractures

Osteoporosis

Pathology

Nature Reviews Disease Primers

Bone stress injuries, including stress fractures, are overuse injuries that lead to substantial morbidity in active individuals. These injuries occur when excessive repetitive loads are introduced to a generally normal skeleton. Although the precise mechanisms for bone stress injuries are not completely understood, the prevailing theory is that an imbalance in bone metabolism favours microdamage accumulation over its removal and replacement with new bone via targeted remodelling. Diagnosis is achieved by a combination of patient history and physical examination, with imaging used for confirmation. Management of bone stress injuries is guided by their location and consequent risk of healing complications. Bone stress injuries at low-risk sites typically heal with activity modification followed by progressive loading and return to activity. Additional treatment approaches include non-weight-bearing immobilization, medications or surgery, but these approaches are usually limited to managing bone stress injuries that occur at high-risk sites. A comprehensive strategy that integrates anatomical, biomechanical and biological risk factors has the potential to improve the understanding of these injuries and aid in their prevention and management. Bone stress injuries, commonly referred to as stress reactions or stress fractures, result from repeated overloading of bone and are thought to involve an imbalance in microdamage formation and repair. This Primer provides an overview of the epidemiology, pathobiology, risk factors, diagnostic approaches, treatments and consequences of bone stress injuries.

Bone stress injuries