Gene

microRNA

Cell biology

Extracellular vesicles

Monocyte

Biology

Microvesicles

Extracellular

Cancer research

Biochemistry

Triple-negative breast cancer

Human breast

Immunology

Genetics

Immune system

In vitro

Macrophage

Inflammation

Tumor microenvironment

Internal medicine

Proinflammatory cytokine

Medicine

Chemistry

Breast tumor

Breast cancer

Cancer

Proceedings of the National Academy of Sciences

Significance Our work uncovers mechanisms by which tumor cells impact tumor-associated macrophages in human triple-negative breast cancer. Via extracellular vesicles (EVs), these tumors promote macrophages with proinflammatory features, correlated with better clinical outcome. Our results suggest exploration of these EVs as tools, alone, or in combination with other therapies, to promote a favorable environment for the generation of anti-tumor immune responses.

Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome