Quantum mechanics

Ultrasound

Engineering

Biomedical engineering

Materials science

Telecommunications

Power (physics)

Stimulation

Computer science

Energy harvesting

Acoustics

Therapeutic ultrasound

Physics

Central nervous system

Midbrain

Internal medicine

Composite material

Periaqueductal gray

Medicine

Piezoelectricity

Wireless

Electrical engineering

Science Advances

Supplying wireless power is a challenging technical problem of great importance for implantable biomedical devices. Here, we introduce a novel implantable piezoelectric ultrasound energy–harvesting device based on Sm-doped Pb(Mg 1/3 Nb 2/3 )O 3 -PbTiO 3 (Sm-PMN-PT) single crystal. The output power density of this device can reach up to 1.1 W/cm 2 in vitro, which is 18 times higher than the previous record (60 mW/cm 2 ). After being implanted in the rat brain, under 1-MHz ultrasound with a safe intensity of 212 mW/cm 2 , the as-developed device can produce an instantaneous effective output power of 280 μW, which can immediately activate the periaqueductal gray brain area. The rat electrophysiological experiments under anesthesia and behavioral experiments demonstrate that our wireless-powered device is well qualified for deep brain stimulation and analgesia applications. These encouraging results provide new insights into the development of implantable devices in the future.

Piezoelectric ultrasound energy–harvesting device for deep brain stimulation and analgesia applications