Rechargeable aqueous zinc-ion batteries (ZIBs) have attracted extensive attention due to their low cost and high safety. However, the critical issues of dendrite growth and side reactions on the Zn metal anode hinder the commercialization of ZIBs. Herein, we demonstrated that the formation of Zn<sub>4</sub>SO<sub>4</sub>(OH)<sub>6</sub>·5H<sub>2</sub>O byproducts is closely relevant to the direct contact between the Zn electrode and SO<sub>4</sub><sup>2-</sup>/H<sub>2</sub>O. On the basis of this finding, we developed a cation-exchange membrane of perfluorosulfonic acid (PFSA) coated on the Zn surface to regulate the Zn plating/stripping behavior. Importantly, the PFSA film with abundant sulfonic acid groups could simultaneously block the access of SO<sub>4</sub><sup>2-</sup> and H<sub>2</sub>O, accelerate the Zn<sup>2+</sup> ion transport kinetics, and uniformize the electrical and Zn<sup>2+</sup> ion concentration field on the Zn surface, thus achieving a highly reversible Zn plating/stripping process with corrosion-free and dendrite-free behavior. Consequently, the PFSA-modified Zn anode exhibits high reversibility with 99.5% Coulombic efficiency and excellent plating/stripping stability (over 1500 h), subsequently enabling a highly rechargeable Zn-MnO<sub>2</sub> full cell. The strategy of the cation-exchange membrane proposed in this work provides a simple but efficient method for suppression of side reactions.