Phenotype

Pathology

Biotechnology

In vivo

Tumor microenvironment

Immunotherapy

Hepatocellular carcinoma

Biology

Gene

Immunology

Ex vivo

T cell

Mass cytometry

Flow cytometry

Cancer research

Biochemistry

Medicine

Immune system

Journal of Hepatology

Despite recent translation of immunotherapies into clinical practice, the immunobiology of hepatocellular carcinoma (HCC), in particular the role and clinical relevance of exhausted and liver-resident T cells remain unclear. We therefore dissected the landscape of exhausted and resident T cell responses in the peripheral blood and tumor microenvironment of patients with HCC.

T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma