The effects of the coronavirus disease (COVID-19) pandemic cuts across every facet of a nation’s life. The near collapse of economies with the attendant job losses has brought forth the need for effective social policies, particularly in developing countries, that can serve citizens in dire need. Consequently, many of these countries have had to craft emergency social policies to help their citizens. Ghana is no exception. While measures to control the spread of the pandemic, such as lockdowns and restrictions on movement and gathering, were timely, they negatively impacted the poor, most of whom work in the informal sector and depend on daily survival activities such as buying and selling basic goods. As a result, some of the measures were ignored as people feared they would die from hunger rather than from the pandemic. Thus, governmental response to the pandemic was highlighted by policy layering and exposed the fragile social support systems in existence. The challenges of responding adequately to the pandemic underscore the importance of a transformative social welfare regime in ensuring the protection of citizens. This paper, based on desk research, explores the limitations of the existing social policy framework, which became manifest during the implementation of Ghana’s pandemic policies. Policy layering by government continues to weaken Ghana’s social welfare system, and this affected the official response with respect to the social issues that have emerged due to the pandemic.