Heterocyclic compounds such as spirooxindole, with five rings containing nitrogen, have an important role in the realm of medicine. This study aims to synthesize the spirooxindole derivative compounds using Fe 3 O 4 /graphene oxide (GO) nanocomposite as the catalyst. The GO sample was synthesized by Hummers' method, followed by the insertion of Fe 3 O 4 into the graphene oxide layers by the co-precipitation method. Both XRD and FTIR analyses reveal that GO and Fe 3 O 4 /GO samples have been successfully formed. SEM-EDX micrograph supported by TEM image indicates that the Fe 3 O 4 nanoparticles in the composite have excellent dispersibility, attributable to the existence of the GO sheets. The evaluation of the ability of Fe 3 O 4 /GO as a catalyst in the synthesis of spirooxindole derivatives was carried out by the one-pot three-component method. The reaction yield shows that Fe 3 O 4 /GO was a suitable and reusable catalyst in this reaction.