Cerebrospinal fluid

Context (archaeology)

Cell biology

Haematopoiesis

Neuroscience

Biology

Stem cell

Bone marrow

Paleontology

Immunology

Meninges

Myeloid

Spinal cord

Immune system

Skull

Anatomy

Medicine

Myelopoiesis

Pathology

Nature Neuroscience

It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels