Biology

Percentile

Statistics

Perimeter

Surgery

Ophthalmology

Retinopathy of prematurity

Multivariate analysis

Birth weight

Genetics

Pediatrics

Mathematics

Gestational age

Internal medicine

Univariate analysis

Geometry

Prospective cohort study

Medicine

Pregnancy

British Journal of Ophthalmology

Background/aims To evaluate whether anterior segment anatomy and axial length are associated with prematurity and perinatal factors in adults. Methods The Gutenberg Prematurity Eye Study examined adults born preterm and term aged 18–52 years. All participants underwent a prospective ophthalmic examination (optical biometry via a LenStar 900, Haag-Streit) in Germany. The associations between gestational age (GA), birth weight (BW) and BW percentile, retinopathy of prematurity (ROP) occurrence, ROP treatment and other perinatal factors with the main outcome measures were evaluated by univariate and multivariable linear regression analyses. Main outcome measures were corneal radius, white-to-white distance, anterior chamber depth, lens thickness and axial length. Results The study involved 861 eyes of 438 preterm and full-term individuals (aged 28.6±8.7 years, 245 females,). After adjustment for age and gender, a steeper corneal radius was associated with lower GA (B=0.02; p&lt;0.001) and a lower BW percentile (B=0.003; p&lt;0.001). A smaller white-to-white distance was linked to lower GA (B=0.02; p&lt;0.001), a lower BW percentile (B=0.004; p&lt;0.001) and postnatal ROP occurrence (B=−0.26; p&lt;0.001). Decreased axial length was associated with lower GA at birth (B=0.05; p=0.002) and pre-eclampsia (B=−0.34; p=0.015). ROP-treated eyes had a shallower anterior chamber depth (B=−0.63; p=0.001) and increased lens thickness (B=0.64, p&lt;0.001). Conclusion Our analyses in adults demonstrate that the corneal morphology is influenced by GA and BW percentile, while the anterior chamber depth and lens thickness are affected by ROP treatment, namely laser therapy and cryotherapy. The present study highlights that perinatal factors lead to lifelong sequelae of ocular shape.

Ocular geometry in adults born extremely, very and moderately preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Eye Study