Internal medicine

Receptor

Knockout mouse

Disease

Methionine

Biology

Gene

Endocrinology

Proinflammatory cytokine

Chemistry

In vitro

Steatosis

Hepatocyte

Inflammation

Steatohepatitis

Fatty liver

RNA splicing

XBP1

Amino acid

Biochemistry

Medicine

Journal of Hepatology

Non-alcoholic steatohepatitis (NASH) is associated with the dysregulation of lipid metabolism and hepatic inflammation, though the underlying mechanisms remain unclear. We aimed to investigate the role of X-box binding protein-1 (XBP1) in the progression of NASH.

Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis