Cytoskeleton

Cell

Neuroscience

Microtubule

Central nervous system

Biology

Motor protein

Neurofilament

Immunohistochemistry

Immunology

Motor neuron

Axotomy

Axon

Soma

Spinal cord

Axoplasmic transport

Cell biology

Genetics

Intermediate filament

Frontiers in Cell and Developmental Biology

Neurofilament light (NFL) is one of the proteins forming multimeric neuron-specific intermediate filaments, neurofilaments, which fill the axonal cytoplasm, establish caliber growth, and provide structural support. Dominant missense mutations and recessive nonsense mutations in the neurofilament light gene (

Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons