Physics

Organic chemistry

Combinatorial chemistry

Catalysis

Lewis acids and bases

Chemistry

Condensed matter physics

Acid catalysis

Acceptor

Acetaldehyde

Aldehyde

Ethanol

Polymerization

Polymer

Brønsted–Lowry acid–base theory

Angewandte Chemie International Edition

High acidity and structural confinement are pivotal elements in asymmetric acid catalysis. The recently introduced imidodiphosphorimidate (IDPi) Brønsted acids have met with remarkable success in combining those features, acting as powerful Brønsted acid catalysts and “silylium” Lewis acid precatalysts in numerous thus far inaccessible transformations. Substrates as challenging to activate as simple olefins were readily transformed, ketones were employed as acceptors in aldolizations allowing sub‐ppm level catalysis, whereas enolates of the smallest donor aldehyde, acetaldehyde, did not polymerize but selectively added a single time to a variety of acceptor aldehydes.

IDPi Catalysis