Gene

Cell biology

Immune receptor

Pattern recognition receptor

Biology

Acquired immune system

Receptor

Immunity

Signal transduction

Plant Immunity

Plant disease resistance

R gene

Computational biology

Immunology

Genetics

Arabidopsis

Immune system

Mutant

Innate immune system

The Plant Cell

Understanding the plant immune system is crucial for using genetics to protect crops from diseases. Plants resist pathogens via a two-tiered innate immune detection-and-response system. The first plant Resistance (R) gene was cloned in 1992 . Since then, many cell-surface pattern recognition receptors (PRRs) have been identified, and R genes that encode intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) have been cloned. Here, we provide a list of characterized PRRs and NLRs. In addition to immune receptors, many components of immune signaling networks were discovered over the last 30 years. We review the signaling pathways, physiological responses, and molecular regulation of both PRR- and NLR-mediated immunity. Recent studies have reinforced the importance of interactions between the two immune systems. We provide an overview of interactions between PRR- and NLR-mediated immunity, highlighting challenges and perspectives for future research.

Thirty years of resistance: Zig-zag through the plant immune system