Multicenter trial

Engineering

Modified Rankin Scale

Surgery

Clinical trial

Ischemia

Basilar artery

Mechanical engineering

Acute stroke

Occlusion

Multicenter study

Stroke (engine)

Endovascular treatment

Physical therapy

Internal medicine

Medicine

Clinical equipoise

Tissue plasminogen activator

Randomized controlled trial

Aneurysm

Ischemic stroke

International Journal of Stroke

Recently, two multicenter randomized controlled trials (RCT) failed to show a significantly beneficial effect of endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO). However, both trials suffered from equipoise issues which may have hindered the validity of the trial results. Therefore, additional RCT studies are needed to explore the potential benefit of EVT in patients presenting with BAO.ATTENTION is an investigator-initiated, multicenter, prospective, randomized, controlled clinical trial with open-label treatment and blinded outcome assessment (PROBE) of EVT versus best medical management (BMM). The primary effect parameter is a modified Rankin Score of 0-3 at day 90.ATTENTION will provide evidence for the efficacy and safety of EVT in stroke patients within 12 h after BAO.ClinicalTrials.gov NCT04751708.

Endovascular treatment for acute basilar artery occlusion: A multicenter randomized controlled trial (ATTENTION)