Flow chemistry

Nanotechnology

Organic chemistry

Enzyme

Combinatorial chemistry

Compartmentalization (fire protection)

Microreactor

Engineering

Catalysis

Chemistry

Materials science

Emulsion

Cascade

Pickering emulsion

Chemical engineering

Chromatography

Cascade reaction

Nature Communications

A continuous flow cascade of multi-step catalytic reactions is a cutting-edge concept to revolutionize stepwise catalytic synthesis yet is still challenging in practical applications. Herein, a method for practical one-pot cascade catalysis is developed by combining Pickering emulsions with continuous flow. Our method involves co-localization of different catalytically active sub-compartments within droplets of a Pickering emulsion yielding cell-like microreactors, which can be packed in a column reactor for continuous flow cascade catalysis. As exemplified by two chemo-enzymatic cascade reactions for the synthesis of chiral cyanohydrins and chiral ester, 5 − 420 fold enhancement in the catalysis efficiency and as high as 99% enantioselectivity were obtained even over a period of 80 − 240 h. The compartmentalization effect and enriching-reactant properties arising from the biomimetic microreactor are theoretically and experimentally identified as the key factors for boosting the catalysis efficiency and for regulating the kinetics of cascade catalysis.

Pickering emulsion droplet-based biomimetic microreactors for continuous flow cascade reactions