Organic chemistry

Combinatorial chemistry

Stereochemistry

Catalysis

Computational chemistry

Chemistry

Phenanthrene

Acenaphthylene

Molecule

Oxindole

Quantum chemical

Antimicrobial

Molecules

A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical calculations studies, using the DFT approach, were performed to rationalize the stereochemical outcome. These

Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds