Electrode

Organic chemistry

Reactive intermediate

Combinatorial chemistry

Cyclic voltammetry

Surface modification

Catalysis

Stoichiometry

Physical chemistry

Chemistry

Acylation

Ferrocene

Supporting electrolyte

Cyclic amines

Alkyl

Aryl

Electrolyte

Electrochemistry

Redox

Regioselectivity

Angewandte Chemie International Edition

Herein, we disclose a straightforward, robust, and simple route to access β‐substituted desaturated cyclic amines via an electrochemically driven desaturative β‐functionalization of cyclic amines. This transformation is based on multiple single‐electron oxidation processes using catalytic amounts of ferrocene. The reaction proceeds in the absence of stoichiometric amounts of electrolyte under mild conditions, affording the desired products with high chemo‐ and regioselectivity. The reaction was tolerant of a broad range of substrates and also enables late‐stage β‐C(sp 3 )−H acylation of potentially valuable products. Preliminary mechanistic studies using cyclic voltammetry reveal the key role of ferrocene as a redox mediator in the reaction.

Electrochemical Desaturative β‐Acylation of Cyclic <i>N</i>‐Aryl Amines

Electrochemical Desaturative β‐Acylation of Cyclic N‐Aryl Amines