Reformatsky reaction as a key step in the synthesis of natural products: A review

Reformatsky reaction holds a prominent place in synthetic chemistry as it provides a unique route to build carbon-carbon bond. In this reaction, aldehydes or ketones react with α-halocarbonyl compounds in the presence of metal catalysts to produce β-hydroxy alkanoates. S. N. Reformatsky discovered this transformation in 1887 and it has a wide range of applications in the total synthesis of various natural compounds. In this account, attention...