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Review paper

Reformatsky reaction as a key step in the synthesis of natural products: A review

Volume: 52, Issue: 3, Pages: 317 - 345
Published: Nov 29, 2021
Abstract
Reformatsky reaction holds a prominent place in synthetic chemistry as it provides a unique route to build carbon-carbon bond. In this reaction, aldehydes or ketones react with α-halocarbonyl compounds in the presence of metal catalysts to produce β-hydroxy alkanoates. S. N. Reformatsky discovered this transformation in 1887 and it has a wide range of applications in the total synthesis of various natural compounds. In this account, attention...
Paper Details
Title
Reformatsky reaction as a key step in the synthesis of natural products: A review
Published Date
Nov 29, 2021
Volume
52
Issue
3
Pages
317 - 345
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