FOXO1 represses lymphatic valve formation and maintenance via PRDM1

•FOXO1 represses lymphatic valve formation and maintenance in the mouse mesentery•FOXO1 represses the expression of lymphatic-valve-specific genes via PRDM1•Oscillatory shear stress inactivates FOXO1 via Akt and reduces PRDM1 expression•Genetic reduction of Prdm1 rescues valve loss in Foxo1-overexpressing mice Intraluminal lymphatic valves (LVs) contribute to the prevention of lymph backflow and maintain circulatory homeostasis. Several reports...