Original paper
Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential
Abstract
CD4+ T cells have a remarkable potential to differentiate into diverse effector lineages following activation. Here, we probe the heterogeneity present among naive CD4+ T cells before encountering their cognate antigen to ask whether their effector potential is modulated by pre-existing transcriptional and chromatin landscape differences. Single-cell RNA sequencing shows that key drivers of variability are genes involved in T cell receptor (TCR)...
Paper Details
Title
Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential
Published Date
Nov 1, 2021
Journal
Volume
37
Issue
9
Pages
110064 - 110064
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History