Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases
Abstract
Cardiometabolic diseases are frequently polygenic in architecture, comprising a large number of risk alleles with small effects spread across the genome1–3. Polygenic scores (PGS) aggregate these into a metric representing an individual’s genetic predisposition to disease. PGS have shown promise for early risk prediction4–7 and there is an open question as to whether PGS can also be used to understand disease biology8. Here, we demonstrate that...
Paper Details
Title
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases
Published Date
Nov 8, 2021
Journal
Volume
3
Issue
11
Pages
1476 - 1483
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