Nuclear chemistry

Nanoparticle

Metallurgy

Materials science

Chelation

Biological activity

Biochemistry

Inorganic chemistry

Lanthanum

Nanotechnology

Organic chemistry

Nuclease

In vitro

Antioxidant

Enzyme

Chemistry

Viability assay

DPPH

Advanced Powder Technology

The enhanced biological activity of perovskite type La1-xBaxMnO3 (x = 0.2, 0.3, 0.4) nanoparticle was studied based on antioxidant, antimicrobial, anti-biofilm, bacterial viability inhibition, and DNA cleavage studies. The nanoparticles were prepared by Sol-gel technique and they were analyzed on structure and morphological by XRD and SEM. La0.6Ba0.4MnO3 showed the highest DPPH free radical scavenging activity and iron chelating activity as 67.23% and 46.54%, respectively. All tested lanthanum nanoparticles showed good chemical nuclease activity. C. tropicalis was the most affected species by lanthanum nanoparticles and MIC values were 4 µg/mL, 8 µg/mL, and 16 µg/mL for La0.7Ba0.4MnO3, La0.6Ba0.4MnO3, and La0.8Ba0.2MnO3, respectively. La0.7Ba0.4MnO3 exhibited the highest percentage of biofilm inhibition against P. aeruginosa and S. aureus as 99.78% and 98.38%, respectively. Cell viability assay demonstrated that La0.7Ba0.4MnO3, La0.6Ba0.4MnO3, and La0.8Ba0.2MnO3 showed %100 cell viability inhibition after 30 and 60 min treatment.

Synthesis and characterization of perovskite type of La1-xBaxMnO3 nanoparticles with investigation of biological activity