Original paper
Integrated stress response restricts macrophage necroptosis
Abstract
The integrated stress response (ISR) regulates cellular homeostasis and cell survival following exposure to stressors. Cell death processes such as apoptosis and pyroptosis are known to be modulated by stress responses, but the role of the ISR in necroptosis is poorly understood. Necroptosis is an inflammatory, lytic form of cell death driven by the RIPK3-MLKL signaling axis. Here, we show that macrophages that have induced the ISR are protected...
Paper Details
Title
Integrated stress response restricts macrophage necroptosis
Published Date
Nov 11, 2021
Journal
Volume
5
Issue
1
Pages
e202101260 - e202101260
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Notes
History