DeepTOFSino: A deep learning model for synthesizing full-dose time-of-flight bin sinograms from their corresponding low-dose sinograms

Reducing the injected activity and/or the scanning time is a desirable goal to minimize radiation exposure and maximize patients' comfort. To achieve this goal, we developed a deep neural network (DNN) model for synthesizing full-dose (FD) time-of-flight (TOF) bin sinograms from their corresponding fast/low-dose (LD) TOF bin sinograms. Clinical brain PET/CT raw data of 140 normal and abnormal patients were employed to create LD and FD TOF bin...