Review paper
Generation of heart-forming organoids from human pluripotent stem cells
Abstract
Heart-forming organoids (HFOs) derived from human pluripotent stem cells (hPSCs) are a complex, highly structured in vitro model of early heart, foregut and vasculature development. The model represents a potent tool for various applications, including teratogenicity studies, gene function analysis and drug discovery. Here, we provide a detailed protocol describing how to form HFOs within 14 d. In an initial 4 d preculture period, hPSC...
Paper Details
Title
Generation of heart-forming organoids from human pluripotent stem cells
Published Date
Nov 10, 2021
Journal
Volume
16
Issue
12
Pages
5652 - 5672
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