Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses
Abstract
Humoral immunity is essential for protection against pathogens, emphasized by the prevention of 2-3 million deaths worldwide annually by childhood immunizations. Long-term protective immunity is dependent on the continual production of neutralizing antibodies by the subset of long-lived plasma cells (LLPCs). LLPCs are not intrinsically long-lived, but require interaction with LLPC niche stromal cells for survival. However, it remains unclear...
Paper Details
Title
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses
Published Date
Dec 1, 2021
Journal
Volume
54
Issue
12
Pages
2772 - 2783.e5
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Notes
History