Internal medicine

Pathology

Autophagy

Oxidative stress

Inflammatory bowel disease

Disease

Pathogenesis

Colorectal cancer

Bioinformatics

Biology

Necroptosis

Cancer

Apoptosis

GPX4

Immunology

Inflammation

Glutathione peroxidase

Catalase

Programmed cell death

Cancer research

Gastrointestinal cancer

Biochemistry

Medicine

International Journal of Molecular Sciences

Ferroptosis is a novel form of regulated cell death (RCD) that is typically accompanied by iron accumulation and lipid peroxidation. In contrast to apoptosis, autophagy, and necroptosis, ferroptosis has unique biological processes and pathophysiological characteristics. Since it was first proposed in 2012, ferroptosis has attracted attention worldwide. Ferroptosis is involved in the progression of multiple diseases and could be a novel therapeutic target in the future. Recently, tremendous progress has been made regarding ferroptosis and gastrointestinal diseases, including intestinal ischemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), gastric cancer (GC), and colorectal cancer (CRC). In this review, we summarize the recent progress on ferroptosis and its interaction with gastrointestinal diseases. Understanding the role of ferroptosis in gastrointestinal disease pathogenesis could provide novel therapeutic targets for clinical treatment.

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease