Multi-scale Pan-cancer Integrative Analyses Identify the STAT3-VSIR Axis as a key Immunosuppressive Mechanism in Head and Neck Cancer.

Purpose null VSIR is a novel immune checkpoint protein whose expression on tumor cells across cancers remains largely uncharacterized. Here we purposed to decode the pan-cancer biologic and clinical significance of VSIR over-expression in the tumor compartment. null Experimental design null We performed multi-omics integrative analyses of 9735 tumor samples to identify cancers with non-leukocytic expression of VSIR (VSIR-High), followed by...