Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy
Abstract
To elucidate mechanisms by which T cells eliminate leukemia, we study donor lymphocyte infusion (DLI), an established immunotherapy for relapsed leukemia. We model T cell dynamics by integrating longitudinal, multimodal data from 94,517 bone marrow-derived single T cell transcriptomes in addition to chromatin accessibility and single T cell receptor sequencing from patients undergoing DLI. We find that responsive tumors are defined by enrichment...
Paper Details
Title
Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy
Published Date
Nov 1, 2021
Journal
Volume
37
Issue
6
Pages
109992 - 109992
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Notes
History