Interaction between a fluoroquinolone derivative and RNAs with a single bulge
Abstract
Interaction analysis between small molecules and RNA as well as structure determination of RNA-small molecule complexes will be the clues to search for compounds that bind to specific mRNA or non-coding RNA in drug discovery. In this study, the RNA-binding ability of a fluoroquinolone derivative, KG022, was examined against single-residue bulge-containing hairpin RNAs as RNA models. Nuclear magnetic resonance analysis indicated that KG022...
Paper Details
Title
Interaction between a fluoroquinolone derivative and RNAs with a single bulge
Published Date
Nov 16, 2021
Journal
Volume
171
Issue
2
Pages
239 - 244
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