Downregulation of NF-кB signaling is involved in berberine-mediated protection of crucian carp (Carassius auratus gibelio) from cyprinid herpesvirus 2 infection

An acute cyprinid herpesvirus 2 (CyHV-2) infection of crucian carp (Carassius auratus gibelio) is characterized with hemorrhagic inflammation and high mortality. Berberine is a biologically active plant alkaloid with an anti-inflammation function involving the regulation of transcription factor NF-κB and its downstream inflammation-related genes in mammalian organisms. Our previous study had indicated that BBH (berberine chloride hydrate)...