KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression
Abstract
It is widely recognized that inflammation plays a critical role in cardiac hypertrophy and heart failure. However, clinical trials targeting cytokines have shown equivocal effects, indicating the need for a deeper understanding of the precise role of inflammation and inflammatory cells in heart failure. Leukocytes from human subjects and a rodent model of heart failure were characterized by a marked reduction in expression of Klf2 mRNA. Using a...
Paper Details
Title
KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression
Published Date
Feb 1, 2022
Volume
132
Issue
3
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