Pd-catalyzed Arylation of 1,2-Amino Alcohol Derivatives via beta-Carbon Elimination
Abstract
Herein, we describe a Pd-catalyzed arylation of 1,2-amino alcohols with aryl halides enabled by a retroallylation manifold. This protocol constitutes a new entry point to β-arylated aldehydes via the intermediacy of in situ generated enamine intermediates. The protocol is characterized by its exquisite regioselectivity profile and broad substrate scope – including challenging substrate combinations – even in an enantioselective...
Paper Details
Title
Pd-catalyzed Arylation of 1,2-Amino Alcohol Derivatives via beta-Carbon Elimination
Published Date
Nov 17, 2021
Journal
Volume
33
Issue
01
Pages
52 - 56
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