Octanoic acid–rich enteral nutrition prevented lipopolysaccharide‐induced acute liver injury through c‐Jun N‐terminal kinase–dependent autophagy

Background Acute liver injury (ALI) is an essential component of sepsis associated with poor outcomes. Octanoic acid (OA), a medium‐chain fatty acid, has a protective effect on sepsis‐induced organ damage, and autophagy is an adaptive response to sepsis. However, the underlying mechanism by which OA prevents ALI remains unknown. Therefore, we investigated whether OA‐rich enteral nutrition (EN) prevented lipopolysaccharide (LPS)‐induced ALI...