Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinetic studies
Abstract
G protein-coupled receptors (GPCRs) are an important receptor superfamily and common therapeutic targets. The second messenger cyclic adenosine monophosphate (cAMP) is a key mediator in many GPCR signaling pathways. Monitoring intracellular cAMP levels can help identify orthosteric agonists and antagonists, as well as allosteric modulators. In this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling...
Paper Details
Title
Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinetic studies
Published Date
Jul 1, 2022
Journal
Volume
203
Pages
249 - 258
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