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#1Junfang Fan (BISTU: Beijing Information Science & Technology University)
#2Juanqin Liu (BISTU: Beijing Information Science & Technology University)
Last. Yanhui Wu (BUCM: Beijing University of Chinese Medicine)
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Abstract null null Early screening and diagnosis of cervical precancerous lesions are very important to prevent cervical cancer. High quality colposcopy images will help doctors make faster and more accurate diagnoses. For the purpose of tackling the problem of low image quality caused by complex interference during colposcopy operation, this paper proposed a conditional entropy generation adversarial networks framework for image enhancement. A decomposition network based on Retinex theory is co...
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#1Daphna Harel (NYU: New York University)H-Index: 10
#2Brooke Levis (Keele University)H-Index: 20
Last. Brett D. Thombs (McGill University)H-Index: 67
view all 11 authors...
Shortened versions of self-reported questionnaires may be used to reduce respondent burden. When shortened screening tools are used, it is desirable to maintain equivalent diagnostic accuracy to full-length forms. This manuscript presents a case study that illustrates how external data and individual participant data meta-analysis can be used to assess the equivalence in diagnostic accuracy between a shortened and full-length form. This case study compares the Patient Health Questionnaire-9 (PHQ...
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#1Ikenna C. Okafor (JHU: Johns Hopkins University)H-Index: 1
#2Janice Choi (Johns Hopkins Medicine)
Last. Taekjip Ha (Johns Hopkins Medicine)H-Index: 100
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Abstract null null Like helicases, CRISPR proteins such as Cas9 and Cas12a unwind DNA, but unlike helicases, these CRISPR proteins do not use ATP. Instead, they use binding energy to melt DNA locally and then utilize basepairing between guide (g) RNA and target strand to continue to unwind the DNA. CRISPR Cas9 is the most widely used tool for genome editing applications. The Cas9 endonuclease forms a complex with gRNA that can be programmed to bind a specific 20 bp segment of DNA, the protospace...
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#1Woochang Hwang (University of Cambridge)H-Index: 5
#2Namshik Han (University of Cambridge)H-Index: 11
In the past 20 years, there have been several infectious disease outbreaks in humans for which the causative agent has been a zoonotic coronavirus. Novel infectious disease outbreaks, as illustrated by the current coronavirus disease 2019 (COVID-19) pandemic, demand a rapid response in terms of identifying effective treatments for seriously ill patients. The repurposing of approved drugs from other therapeutic areas is one of the most practical routes through which to approach this. Here, we pre...
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#1Himasha M Perera (Baylor University)H-Index: 2
#2Michael A. Trakselis (Baylor University)H-Index: 22
Abstract null null Helicase enzymes translocate along an RNA or DNA template with a defined polarity to unwind, separate, or remodel duplex strands for a variety of genome maintenance processes. Helicase mutations are commonly associated with a variety of diseases including aging, cancer, and neurodegeneration. Biochemical characterization of these enzymes has provided a wealth of information on the kinetics of unwinding and substrate preferences, and several high-resolution structures of helica...
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#1Chengxin He (SCU: Sichuan University)H-Index: 1
#2Lei Duan (SCU: Sichuan University)H-Index: 7
Last. Longhai Li (SCU: Sichuan University)H-Index: 1
view all 6 authors...
Non-coding RNAs are gaining prominence in biology and medicine, as they play major roles in cellular homeostasis among which the circRNA-miRNA-mRNA axes are involved in a series of disease-related pathways, such as apoptosis, cell invasion and metastasis. Recently, many computational methods have been developed for the prediction of the relationship between ncRNAs and diseases, which can alleviate the time-consuming and labor-intensive exploration involved with biological experiments. However, t...
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#1Thosini Bamunu Mudiyanselage (University of Kelaniya)
#2Xiujuan Lei (SNNU: Shaanxi Normal University)H-Index: 20
Last. Yi Pan (CAS: Chinese Academy of Sciences)H-Index: 70
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Abstract null null Accumulated studies have discovered that circular RNAs (CircRNAs) are closely related to many complex human diseases. Due to this close relationship, CircRNAs can be used as good biomarkers for disease diagnosis and therapeutic targets for treatments. However, the number of experimentally verified circRNA-disease associations are still fewer and also conducting wet-lab experiments are constrained by the small scale and cost of time and labour. Therefore, effective computationa...
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#1Fang I. Wang (UWO: Western University)H-Index: 1
#2Gucci Ding (UWO: Western University)
Last. Peter Chidiac (UWO: Western University)H-Index: 31
view all 5 authors...
Abstract null null G protein-coupled receptors (GPCRs) are an important receptor superfamily and common therapeutic targets. The second messenger cyclic adenosine monophosphate (cAMP) is a key mediator in many GPCR signaling pathways. Monitoring intracellular cAMP levels can help identify orthosteric agonists and antagonists, as well as allosteric modulators. In this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling kinetics. The GloSensor™ cAMP assa...
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#1Yi-Sue Jung (Yonsei University)
#2Yoonbee Kim (Yonsei University)
Last. Young-Rae Cho (Yonsei University)H-Index: 16
view all 3 authors...
Abstract null null Computational prediction of drug–target interactions (DTIs) is of particular importance in the process of drug repositioning because of its efficiency in selecting potential candidates for DTIs. A variety of computational methods for predicting DTIs have been proposed over the past decade. Our interest is which methods or techniques are the most advantageous for increasing prediction accuracy. This article provides a comprehensive overview of network-based, machine learning, a...
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