Noise and dose reduction in CT brain perfusion acquisition by projecting time attenuation curves onto lower dimensional spaces

CT perfusion imaging (CTP) plays an important role in decision making for the treatment of acute ischemic stroke with large vessel occlusion. Since the CT perfusion scan time is approximately one minute, the patient is exposed to a non-negligible dose of ionizing radiation. However, further dose reduction increases the level of noise in the data and the resulting perfusion maps. We present a method for reducing noise in perfusion data based on...