Neuroscience

Gangrene

Gold standard (test)

Biology

Endocrinology

Intensive care medicine

Internal medicine

Sensory loss

Peripheral neuropathy

Medicine

Amputation

Sensation

Surgery

Diabetes mellitus

Complication

Frontiers in Endocrinology

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus. It often causes symmetrical paresthesia, loss of sensation, and hyperalgesia. Without early intervention, it might lead to diabetic foot ulceration, gangrene, and subsequent amputation in people with diabetes. DPN is an insidious disease and often underdiagnosed. This paper reviews the current national and international prevalence of DPN, screening methods for early DPN, including quantitative sensory measurement, neurological function scoring system, confocal microscopy, and high-frequency ultrasound, and summarizes the related research progress, clinical application, and development prospects of these methods in recent years.

Gold Standard for Diagnosis of DPN