Inhibition of corneal neovascularization by topical application of nintedanib in rabbit models

To evaluate the potential efficacy and mechanisms of nintedanib in corneal neovascularization (NV) in rabbit models.Corneal NV was induced using 1 mol/L NaOH. Rabbits (n=21) were randomized to 3 groups: Group 1 were treated with 0.9% NaCl, Group 2 with Avastin (5 mg/mL), and Group 3 with nintedanib (1 mg/mL). All treatments started 1d after alkaline burns and were topically performed 3 times a day for 2wk. Photographs were taken on a slit lamp...