Quantitative SPECT (QSPECT) at high count rates with contemporary SPECT/CT systems

Accurate QSPECT is crucial in dosimetry-based, personalized radiopharmaceutical therapy with 177Lu and other radionuclides. We compared the quantitative performance of three NaI(Tl)-crystal SPECT/CT systems equipped with low-energy high-resolution collimators from two vendors (Siemens Symbia T6; GE Discovery 670 and NM/CT 870 DR).Using up to 14 GBq of 99mTc in planar mode, we determined the calibration factor and dead-time constant under the...