Dynamic competition between a ligand and transcription factor NusA governs riboswitch-mediated transcription regulation

Abstract
Cotranscriptional RNA folding is widely assumed to influence the timely control of gene expression, but our understanding remains limited. In bacteria, the fluoride (F-)-sensing riboswitch is a transcriptional control element essential to defend against toxic F- levels. Using this model riboswitch, we find that its ligand F- and essential bacterial transcription factor NusA compete to bind the cotranscriptionally folding RNA, opposing each...
Paper Details
Title
Dynamic competition between a ligand and transcription factor NusA governs riboswitch-mediated transcription regulation
Published Date
Nov 15, 2021
Volume
118
Issue
47
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