Biomedical engineering

Peptide

Biocompatible material

Functional group

Biochemistry

Physical chemistry

Polymer

Oxidizing agent

Combinatorial chemistry

Organic chemistry

Iodine

Reagent

Hypervalent molecule

Surface modification

Medicine

Chemistry

Chemical modification

Biomolecule

Angewandte Chemie International Edition

Hypervalent iodine compounds are powerful reagents for the development of novel transformations. As they exhibit low toxicity, high functional group tolerance, and stability in biocompatible media, they have been used for the functionalization of biomolecules. Herein, we report recent advances up to June 2021 in peptide and protein modification using hypervalent iodine reagents. Their use as group transfer or oxidizing reagents is discussed in this Minireview, including methods targeting polar, aromatic, or aliphatic amino acids and peptide termini.

Hypervalent Iodine‐Mediated Late‐Stage Peptide and Protein Functionalization