Response to: “Deep Brain Stimulation for Alzheimer's Disease: Tackling Circuit Dysfunction”

The main pathological features in Alzheimer's disease (AD) include amyloid beta plaques, intracellular neurofibrillary tangles, and neuronal loss. Despite encouraging preclinical studies targeting amyloid, tau, and neurodegenerative processes, clinical translation has been less optimistic. On the other hand, addressing brain circuit dysfunction through neuromodulation represents a novel and gestalt treatment strategy in...