Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension

Volume: 321, Issue: 6, Pages: C1010 - C1027
Published: Dec 1, 2021
Abstract
Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary arterial hypertension (PAH). Pulmonary arterial endothelial cells (PAECs) are constantly under mechanic stretch and shear stress that are sufficient to activate Piezo channels. Here, we report that...
Paper Details
Title
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension
Published Date
Dec 1, 2021
Journal
Volume
321
Issue
6
Pages
C1010 - C1027
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