Polyprodrug with ultra-high drug content for tumor intracellular acid-triggered degradation and drug delivery

Polyprodrugs are expected to possess better drug release performance than the conventional polymer prodrugs, because the drug molecules are conjugated in the main chain as structural units, different from the side groups or end groups in the later one. Here, acid-triggered degradable polyprodrug P(DOX-NH) was designed as drug self-delivery system (DSDS) for the tumor intracellular acid-triggered drug delivery, via a facile condensation...